According to a study published in the journal JAMA Surgery, preoperative and postoperative models are highly accurate for predicting breast cancer-related lymphedema (BCRL).

Dr. Danielle H. Rochlin from Memorial Sloan Kettering Cancer Center in New York City, and colleagues conducted a prognostic study involving women with breast cancer who underwent axillary lymphadenopathy surgery (ALND) or lymph node biopsy (SLNB) between 1999 and 2020 to create a simple and accurate predictive model for lymphedema associated with breast cancer. Data were included for 1,882 female patients (mean age 55.6 years).

The researchers found that after a median follow-up of 3.9 years, 11.6 percent of patients were diagnosed with BCRL. The prevalence of breast cancer-related lymphedema in black women was significantly higher than in Asian, Caucasian, and other racial women (22.1% vs 12.5, 10.1%, and 14.8%, respectively). The accuracy for model 1 (preoperative), including age, weight, height, race, status of women with breast cancer who had undergone axillary lymphadenopathy surgery (ALND) or lymph node biopsy (SLNB), radiation therapy, and any chemotherapy was 73.0%, sensitivity is 76.6%, specificity is 72.5%, and area under receiver operating characteristics curve (AUC) is 0.78 at 0.18 cut-off.

For model 2 (postoperative), which included age, weight, race, status of patients with breast cancer who had undergone axillary lymphadenopathy surgery or lymph node biopsy, any chemotherapy, and patient-reported arm swelling, the accuracy was 81.1%, The sensitivity is 78.0%, the specificity is 81.5%, and the area under the receiver operating characteristics curve is 0.86 at the threshold of 0.10. Higher area under receiver operating characteristics curve was seen for both models when authenticating externally or internally.

“By deploying these predictive models in a patient-oriented format in clinical care, our goal is to direct patients to appropriate pre- and postoperative interventions in a way that balances accuracy and practicality,” the authors said.

Source:From the website:vista.gov.vn of national S&T information

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